The purpose of the “Back to Center” advice column is to provide perspectives for personal realignment and empowered living in the COVID era. Sarah encourages you to reach out to her with requests for advice about self-development and emotional and mental well-being in these complicated times. Please send your questions to&nbsp;<a href="mailto:advice@aflds.org">advice@aflds.org</a>. Looking forward to hearing from you!For all other inquiries, please direct your questions to <a href="mailto:info@aflds.org" target="_blank" rel="noopener noreferrer">info@aflds.org</a>.&nbsp;I’ve recently gotten involved with a group that is working to create a vision for a better world as we (hopefully) continue to emerge from COVID. It’s amazing to feel the power of connecting with people who really care about bringing more positivity and love to life, who want to move away from the darkness of the past few years and make something better. There are opportunities for members to share any skills and knowledge they may have that connects with the group’s mission. I had an idea for something I could contribute and actually volunteered to do a presentation for the group. But now I’m having a huge wave of fear and anxiety about it. I haven’t done much public speaking in the past, and I’m really nervous. I’m suddenly doubting whether I have anything of value to offer, and the question “Who am I to do this?” is ringing in my head. I don’t know whether to back out or keep the commitment. Do you have any advice?Thanks for your question! I want to start off by acknowledging your beautiful desire to participate in a group like this and for bravely offering to contribute your own skills! This is amazing.&nbsp;Now, on to your question. I have good news for you: The fact that you are suddenly having these feelings of self-doubt after having stepped out to embrace this new opportunity is a great thing. Want to know why?Whenever we consider taking on a new opportunity or challenge, and that critical inner voice pops up to nag us with the “Who am I?” question, it means that the opportunity holds huge potential for growth. Those doubts are like little flags waving at us to let us know that if we walk forward and take the challenge, we’re going to reach new levels of who we can be. We wouldn’t experience those doubts and fears if there was nothing to be gained. Those feelings mean you are in action in life!You had an initial spark of excitement and inspiration, a thought that you have something to contribute to this group, and you acted on it. The fear is coming to let you know that if you take this opportunity, you will expand yourself in some way. Those scary feelings are never fun, and sometimes we think they’re an indication that we should back out, turn around, and run in the other direction. But if you can shift your perspective to look at them as arrows pointing you toward personal greatness, they can propel you forward into something amazing.So, how do you answer the doubtful voices within? First, write out all your fears. Get all those anxious, doubtful thoughts out into the light on paper. Then, thank your fears! Say, “I know you’re here to help me grow and become more of who I’m meant to be.”Envision how you will grow if you take this opportunity to present to the group, what you will create, how you will feel afterward, who you will be on the other side of it. Take the “Who am I to do this?” question, give the feisty answer, “I’ll tell you who I am to do this!” and write down all the reasons why you are uniquely suited to rock this opportunity!The world desperately needs people like you to bring who they are and what they have to give to help create a brighter future. I urge you to make the decision to let your fears help you step forward and boldly take the challenge, rather than hold you back. I hope you’ll be able to let us know how that presentation goes! All the best!****For as long as I can remember, my son has dreamed of joining the U.S. Army. He’s now almost old enough to enlist, but we’re running into a major problem: the COVID vaccine requirement. Our family is firmly against the vaccine, and definitely oppose the idea of our son getting it. He also doesn’t want the shot, but…his dream. He is heartbroken over the idea of having to give up the army, and we feel torn up about it too. We just want him to be happy and to be able to pursue the path he wants to take in life…Any thoughts on the best way to handle this?This is a really tough situation. I’m so sorry for the pain you and your son are going through over this challenge to his dream. I have a perspective to offer you that I hope will be helpful.&nbsp;Sometimes we run up against obstacles in life that seem immovable, impossible, like they’ll be there forever and there’s nothing we can do about them.&nbsp;But the reality is that life is always moving, shifting, and changing. We’ve certainly seen that over the past few years with COVID. Some mandates we’ve experienced that have at times felt like they were going to become a permanent way of life have in fact changed and lifted. We don’t know what tomorrow will bring, but we can look back over the last few years and see that the passage of time has brought change.It may not be possible for your son to join the army now if he’s not going to comply with the vaccine requirement, but that doesn’t necessarily mean that his dream stops there. The answer may simply be “not now,” but that doesn’t have to mean “never.” Who knows? It may become possible sooner than you think. I encourage you not to give up hope and to help your son to stay positive too.It may feel really hard for your son to have to wait, but it doesn’t mean the time has to feel like a loss. You might try brainstorming together about what he can do to continue to prepare for the army. How can he use this time to be even more ready? What activities can he get involved in that will keep him moving toward his goal, that will keep him feeling excited and hopeful about it? What can help make this waiting time productive and fulfilling?I truly hope your son has the chance to achieve all that he dreams of, and that the journey there will only help him grow. Best wishes to your whole family!&nbsp;****&nbsp;&nbsp;&nbsp;So, I’m visiting my parents right now (we do not live close to each other, so it’s been a long time). The other day, my father mentioned he was going out for an appointment to get his COVID booster shot. Now, I’ve known for a while that my parents are pro-vaccine, but I didn’t expect to be confronted with it so directly during my visit. I was taken by surprise and didn’t know how to react, so I basically said nothing, and off my dad went. Afterward, I kicked myself for making no attempt to talk to him about it before he left. I mean, if I believe these shots are extremely dangerous – which I do – why didn’t I try to get him to reconsider? I guess I might have been thinking about all the times people have tried to convince me to get the vaccine, and how intrusive and so-not-their-business it felt, so maybe I didn’t want to do the same sort of thing to my dad…or maybe I didn’t think talking to him about it would make any difference…or maybe I was scared of how he’d react…I don’t know. I just feel really bad about it now and like I should have spoken up. What do you think?Thanks for writing in! It sounds like it was a tricky moment, and now there’s a lot of self-judgment going on. I hope I can offer some perspectives here that are helpful to you.There are moments where we have a lot of clarity about something we’re presented with, where we know exactly how to act and what to say in the moment, where we respond quickly. Then there are other moments where we’re caught off guard, don’t have our wits about us, don’t know how to handle a situation, and the moment passes. Our tendency can be to come down hard on ourselves after an instance like this: “Why didn’t I speak up?...Why didn’t I act more quickly?...Why couldn’t I get myself together?”But I tend to think that moments like that happen for a reason. Maybe if you had tried to engage your dad in a conversation about the shot, it would have turned into a negative interaction. Maybe he would have been offended or felt it was intrusive. Maybe you would have ended up arguing and saying hurtful things to each other. We don’t know.&nbsp;We all have moments like this, where we don’t act as we think we should have after the fact, and sometimes we can’t understand what in the world just happened. What I’m suggesting is that maybe this doesn’t necessarily equal failure; maybe it’s doors closing on something that’s not meant to be, on words that are better left unspoken for a reason we can’t understand in the moment.I’m not at all absolving anyone of the responsibility to make their best effort to do the right thing in life. What I’m saying is that if we are people who generally try our best to do the right thing, maybe a moment where we don’t act or don’t speak up is exactly what needed to happen.It’s clear from your message that you love your dad and want him to be healthy and well; this incident was not a failure to care. The topic of personal COVID choices is not an easy one to have with those we love. I encourage you to do your best to release the self-judgment and decide how you want to relate to your dad on this issue going forward. Lead with the love you have for him, follow your intuition, and I believe you’ll know what to do. Best wishes for health and wellbeing for your whole family!Previous columns:<ul style="list-style-type:initial;"><li><a href="https://americasfrontlinenews.com/post/back-to-center-the-world-does-not-have-to-understand-or-approve-of-your-choices" target="_blank" rel="noopener noreferrer">'The world does not have to understand or approve of your choices'</a></li><li><a href="https://www.americasfrontlinenews.com/post/back-to-center-i-get-tired-and-overwhelmed" target="_blank" rel="noopener noreferrer">'I get tired and overwhelmed'</a></li><li><a href="https://www.americasfrontlinenews.com/post/back-to-center-i-vacillate-between-feeling-inspired-and-useless" target="_blank" rel="noopener noreferrer">'I vacillate between feeling inspired and useless'</a></li><li><a href="https://americasfrontlinenews.com/post/back-to-center-i-pity-the-people-creating-the-lies" target="_blank" rel="noopener noreferrer">‘I pity the people creating the lies’</a></li><li><a href="https://aflds.org/news/post/back-to-center-the-anger-and-hurt-feelings-are-costing-you-too-much/" target="_blank" rel="noopener noreferrer">‘The anger and hurt feelings are costing you too much’</a></li><li><a href="https://aflds.org/news/post/back-to-center-people-who-once-treated-each-other-with-so-much-love-and-kindness-are-now-at-odds/" target="_blank" rel="noopener noreferrer">‘People who once treated each other with so much love and kindness are now at odds’</a></li><li><a href="https://aflds.org/news/post/back-to-center-struggling-with-my-relationship-with-god-since-covid/" target="_blank" rel="noopener noreferrer">‘Struggling with my relationship with God since COVID’</a></li><li><a href="https://aflds.org/news/post/back-to-center-i-have-lost-confidence-in-our-healthcare-system-including-my-own-personal-doctors/" target="_blank" rel="noopener noreferrer">'I have lost confidence in our healthcare system, including my own personal doctors'</a></li><li><a href="https://aflds.org/news/post/back-to-center-can-you-forgive-yourself-for-the-years-you-couldnt-be-there-with-your-daughter/" target="_blank" rel="noopener noreferrer">'Can you forgive yourself for the years you couldn’t be there with your daughter?'</a></li><li><a href="https://aflds.org/news/post/back-to-center-my-wife-is-willing-to-take-the-sacrifice-for-her-sister-and-im-sick-to-my-stomach-thinking-about-it/" target="_blank" rel="noopener noreferrer">'My wife is willing to take the sacrifice for her sister and I'm sick to my stomach thinking about it'</a></li><li><a href="https://aflds.org/news/post/back-to-center-i-deeply-regret-taking-the-vaccine/" target="_blank" rel="noopener noreferrer">'I deeply regret taking the vaccine'</a></li><li><a href="https://aflds.org/news/post/back-to-center-married-39-years-and-i-thought-we-were-on-the-same-page-when-it-came-to-things-that-mattered-most/" target="_blank" rel="noopener noreferrer">'Married 39 years and I thought we were on the same page when it came to things that mattered most'</a></li><li><a href="https://aflds.org/news/post/back-to-center-how-do-i-repair-this-relationship-or-accept-that-i-may-never-see-my-son-again/" target="_blank" rel="noopener noreferrer">‘How do I repair this relationship or accept that I may never see my son again?’</a></li><li>‘<a href="https://aflds.org/news/post/back-to-center-how-can-i-stop-fear-from-controlling-my-every-thought-and-ruining-my-dreams/" target="_blank" rel="noopener noreferrer">How can I stop fear from controlling my every thought and ruining my dreams?’</a></li><li><a href="https://aflds.org/news/post/how-can-i-pursue-my-dream-to-find-the-person-to-marry-when-its-so-hard-to-connect-with-new-people-because-of-covid/" target="_blank" rel="noopener noreferrer">'How can I pursue my dream to find the person to marry, when it's so hard to connect with new people because of COVID?'</a></li><li><a href="https://www.americasfrontlinedoctors.org/news/post/how-can-i-feel-safe-these-days/" target="_blank" rel="noopener noreferrer">'How can I feel safe these days?'</a></li><li><a href="https://americasfrontlinedoctors.org/news/post/advice-column-premier-back-to-center/" target="_blank" rel="noopener noreferrer">Advice column premier: Back to Center</a></li></ul>Sarah encourages you to reach out to her with requests for advice! Please send your questions to <a href="mailto:advice@aflds.org" target="_blank" rel="noopener noreferrer">advice@aflds.org</a><figure class="image image-style-align-left image_resized" style="width:428px;"><img src="https://aflds.rbrdigital.app/uploads/image_def5830ec1.jpeg"></figure>Sarah Perron is a Certified Transformational Life Coach. Her passion is to help people create a powerful vision for their lives, identify and eliminate anything that holds them back, and step into their own unique greatness and mission in the world. She believes deeply in the power of coaching to bring fresh perspectives, ideas, and motivation to anyone who wants to thrive in life. Sarah works with clients one-on-one and in group coaching programs and presents exciting workshops on self-development topics. You can follow her on her YouTube channel <a href="https://www.youtube.com/channel/UCTlPdMbwe8QAfP5NUR3GRRQ" target="_blank" rel="noopener noreferrer">Find Your Fire</a>.You are invited to book a complimentary coaching call with Sarah! Please visit&nbsp;<a href="https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcalendly.com%2Fsarahperroncoaching%2F45min&amp;data=04%7C01%7Csones%40aflds.org%7C31d93fd5f0224c8ae79008da065d1c0c%7Cb86874a894e144f8891fcd4fa7ac80e6%7C1%7C0%7C637829294605931269%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&amp;sdata=ypWrVm9gI8jDagbivpnoHD1M%2F%2F4CKS4v1YoGUWUGpMQ%3D&amp;reserved=0" target="_blank" rel="noopener noreferrer">https://calendly.com/sarahperroncoaching/45min</a>&nbsp;to choose a time that's convenient&nbsp;for you. She looks forward to meeting you!

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I’m doubting whether I have anything of value to offer, and the question 'Who am I to do this?' is ringing in my head

Back to Center: Who am I to build a better world?

Safe and effective strikes againAccording to many studies and surveys, over 15 percent of people in modern America suffer periods of depression at least once a year, and many, if not most, take prescription drugs of some form to deal with their emotions. Since mental health services are often <a href="https://www.cdc.gov/nchs/covid19/pulse/mental-health-care.htm" target="_blank" rel="noopener noreferrer">difficult to access</a>, as well as expensive, unhealthy use of illicit drugs or alcohol is also common among the depressed.Another approach has been <a href="https://www.statnews.com/2024/04/08/time-is-right-for-over-the-counter-antidepressants/?utm_campaign=pharmalot&amp;utm_medium=email&amp;_hsenc=p2ANqtz-8Xs0nnL7hvSJsSA_go0VKTrwg5g1WD-3UaMxPPiHqSzUA4UiDBBMJIHToSFTM7DOIKFJqZ_ZJFA_fEjnCdtfbQ20iS4UFN7OOhieSR9pgHphbjJII&amp;_hsmi=301755960&amp;utm_content=301755960&amp;utm_source=hs_email" target="_blank" rel="noopener noreferrer">proposed </a>by Roy Perlis, a professor of psychiatry at Harvard Medical School and associate chief for research in the Department of Psychiatry at Massachusetts General Hospital in Boston. Noting that oral contraceptives are now available over-the-counter without a prescription, he suggests that the same should apply for the class of anti-depressant drugs known as SSRIs. After all, he claims, they are “safe and effective”:<blockquote>These medications, which have been used in the U.S. for three decades, have repeatedly been shown to be safe and effective for treating major depression and anxiety disorders.</blockquote>&nbsp;Downplaying suicide risk, homicide risk unmentionedAfter making that categorical statement on safety and effectiveness, Perlis admits that “depression is associated with increased risk for suicide and medication overdose is among the most common methods of suicide.” He claims, however, that the increased suicide risk associated with SSRIs only applies to those under the age of 25 and then only “modestly,” and that for those above this age, there is no increased risk.Based on a wealth of data, Professor Peter Gotzsche, one of the founders of the Cochrane Collaboration, concludes that <a href="https://www.madinamerica.com/2024/04/prescription-drugs-are-the-leading-cause-of-death/" target="_blank" rel="noopener noreferrer">SSRIs are far more dangerous</a> than Prof. Perlis asserts. Aside from their links to suicide (and also <a href="https://www.bmj.com/content/358/bmj.j3697/rr-4" target="_blank" rel="noopener noreferrer">homicide</a>) which apply to those over the age of 25 as well, SSRIs are also linked to events that few people would consider as being associated, such as falls in the elderly (which often contribute to death), as anti-depressants cause orthostatic hypertension, confusion, and dizziness. Given that the link is indirect, studies that investigate the dangers of SSRIs will usually miss such risks.SSRIs are also linked to <a href="https://frontline.news/post/study-depression-in-an-expectant-mother-doesn-t-harm-her-baby-anti-depressants-do" target="_blank" rel="noopener noreferrer">dangers</a> for unborn babies, and while this also applies to many OTC drugs making SSRIs so readily available may contribute to a perception that they are safe for pregnant women.Anti-depressants linked to antibiotic resistanceAn interesting <a href="https://pubmed.ncbi.nlm.nih.gov/36689653/" target="_blank" rel="noopener noreferrer">study</a> published in 2023 has also linked use of anti-depressants to antibiotic resistance, a growing and under-publicized problem across the world, providing another reason to restrict access to these drugs. The study's authors note that,<blockquote>Antidepressants are consumed in large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While antibiotics are acknowledged as the major driver of increasing antibiotic resistance, little attention is paid to the contribution of antidepressants in this process.</blockquote>&nbsp;Meanwhile, the idea of freely available ketamine sparks alarmNot too long ago, Elon Musk sparked controversy when he spoke about his use of ketamine to treat depression.<div class="raw-html-embed"><blockquote class="twitter-tweet">Depression is overdiagnosed in the US, but for some people it really is a brain chemistry issue. But zombifying people with SSRIs for sure happens way too much. From what I’ve seen with friends, ketamine taken occasionally is a better option.— Elon Musk (@elonmusk) <a href="https://twitter.com/elonmusk/status/1673567124768317440?ref_src=twsrc%5Etfw">June 27, 2023</a></blockquote> <script async="" src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>Interestingly, many doctors were quick to condemn ketamine and claim that SSRIs are safer. According to <a href="https://www.sciencemediacentre.org/expert-reaction-to-comments-by-elon-musk-about-use-of-ketamine-for-depression/" target="_blank" rel="noopener noreferrer">Dr. R. McShane</a>, associate professor at the Department of Psychiatry at the University of Oxford,&nbsp;<blockquote>Using ketamine as the first alternative instead of an SSRI is not something I would recommend … The risks of long term ketamine include tolerance, which depends on the dose and how frequently it is taken. The risks of long term SSRIs are better understood.</blockquote>Dr. McShane added that,&nbsp;<blockquote>People who try to treat themselves without medical help tend to take more ketamine (ie higher doses and more frequently) than if they were being prescribed it medically.</blockquote>Presumably, this argument could be extended to any OTC medication, including SSRIs if they become OTC.&nbsp;Just waiting for a brave Pharma company to step upProf. Perlis concludes his article with the hope that,&nbsp;<blockquote>… an SSRI manufacturer [will emerge] with the courage to engage with the FDA and invest the necessary resources for a prescription-to-OTC switch, a well-trod path…</blockquote>Clearly, he is convinced that SSRIs fulfill the FDA's <a href="https://www.fda.gov/drugs/drug-application-process-nonprescription-drugs/prescription-nonprescription-rx-otc-switches" target="_blank" rel="noopener noreferrer">criteria </a>for OTC drugs: they can be used for self-diagnosed conditions; there is no need for a doctor's involvement to ensure safe usage; and there is only a “low” potential that the drugs will be misused or abused.For other <a href="https://www.mdedge.com/psychiatry/article/105092/depression/should-ssris-be-sold-over-counter" target="_blank" rel="noopener noreferrer">psychiatrists</a> (and many laypeople), the idea remains “unthinkable.”<blockquote>These medications, after all, carry a black box warning…</blockquote>

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Psychiatric Drug

Why not? After all, they are 'proven' safe and effective...

OTC anti-depressants? Harvard Medical School professor says yes

<h2>Understanding synthetic biology (synbio)</h2><h3>What it is</h3>We've been hearing a lot about synthetic biology in terms of synthetic foods, yet synbio is more than just an attempt to recreate food, which Frontline News has <a href="https://frontline.news/post/got-milk-it-may-not-be-real" target="_blank" rel="noopener noreferrer">written</a> about in relationship to synthetic “milk.” Synbio genetic engineers are also interested in reproducing biological organisms and creating new biological products not found in nature. Following are a few definitions of synbio to show what it encompasses:<a href="https://en.wikipedia.org/wiki/Synthetic_biology" target="_blank" rel="noopener noreferrer">Wikipedia</a> - making new biological products or redesigning existing ones:<blockquote>Synthetic biology is a multidisciplinary field of science that focuses on living systems and organisms, and it applies engineering principles to develop new biological parts, devices, and systems or to redesign existing systems found in nature. -&nbsp;</blockquote><a href="https://www.newhope.com/industry-insights/synthetic-biology-test-could-force-the-natural-products-industry-to-define-its-position" target="_blank" rel="noopener noreferrer">New Hope Network</a> - using fermentation as mini-factories to recreate natural products:<blockquote>Ultimately, synbio is an attempt to re-create something that occurs in nature by using microorganisms to act as mini-factories,” explains Dana Perls, food and technology program manager at Friends of the Earth.&nbsp;</blockquote><a href="https://www.genome.gov/about-genomics/policy-issues/Synthetic-Biology" target="_blank" rel="noopener noreferrer">Genome.gov</a> - redesigning organisms for new purposes and recreating substances in nature through artificial means:<blockquote>Synthetic biology is a field of science that involves redesigning organisms for useful purposes by engineering them to have new abilities. Synthetic biology researchers and companies around the world are harnessing the power of nature to solve problems in medicine, manufacturing and agriculture.Redesigning organisms so that they produce a substance, such as a medicine or fuel, or gain a new ability, such as sensing something in the environment, are common goals of synthetic biology projects.&nbsp;</blockquote><a href="https://www.ecofarmingdaily.com/culture-of-disruption/" target="_blank" rel="noopener noreferrer">Jim Thomas, in an interview with Eco Farming Daily</a> - treating biology as a computer program (Jim Thomas is a technology historian and long-time critic of the biotech industry):<blockquote>The core assumptions of synthetic biology are that life is a sort of computer program, that DNA is like a code and that a cell or living organism is like a computer or a machine. As long as you can “reprogram” the DNA — the instructions — then you can engineer the machine to do whatever you want it to do.&nbsp;</blockquote><h3>Products created using synthetic biology</h3><a href="https://www.newhope.com/industry-insights/synthetic-biology-test-could-force-the-natural-products-industry-to-define-its-position" target="_blank" rel="noopener noreferrer">New Hope Network</a> author Melaina Juntti said that many synbio products are already in many foods and are finding their way into dietary supplement supply chains, also. She referred to the Non-GMO Project's director of marketing and communications, Hans Eisenbeis, who said that some synbio products have already been commercialized or are in development such as “vanillin and other flavorings, several colorants, CBD, collagen, plant-based proteins, dairy proteins, vitamins, omegas, probiotics and dairy milk proteins.”&nbsp;In addition to Eisenbeis's list, Health Research Institute–HRI Labs chairman and chief scientist, John Fagan, Ph.D., added “astaxanthin, resveratrol, and squalene to the growing list.”<a href="https://www.nature.com/articles/s41467-020-20122-2" target="_blank" rel="noopener noreferrer">Nature</a> provides this list of synbio&nbsp;generated products:<ul><li>Hemme used to make the “blood” for the Impossible Burger: “The yeast Pichia pastoris was engineered to produce soy leghemoglobin, which improves meaty flavors and aromas when added to a plant-based burger.”</li><li>Other synbio products created by fermenting yeast include Vitamin E, stevia, and milk whey. Plant pathways to pharmaceuticals include taxadiene (Taxol precursor), steroids, THC, and opiates. “An early landmark achievement to make the anti-malarial Artimisin was taken into production by Sanofi, but was discontinued because the cost was higher than sourcing it from the plant.”</li><li>Januvia (sitgaliptin) is a diabetes medication manufactured by Merck. “It is the 95th most-prescribed drug with ~107 prescriptions and $1.35 billion in annual sales.”</li><li>Hyaline transparent and flexible film for electronics.&nbsp;</li><li>ProveN fertilizer being applied to corn. “Pivot Bio has created the first biological fertilizer for corn based on a γ-proteobacterium (KV137) that associates with corn roots and has the necessary genes to fix nitrogen. However, the genes are off when most needed, so synthetic biology was used to turn the genes on, which guided the remodeling of the KV137 genome.”</li><li>Kymriah, a treatment for B-cell acute lymphoblastic leukemia by Novartis, is produced by genetically modifying a patient’s T cells and is deemed an “effective living therapy.” Using engineered living cells for therapeutic purposes has been considered to be the “3rd pillar of medicine.” &nbsp;Kymriah (Tisagenlecleucel) is the first of its type to receive FDA approval.</li><li>Calyno high-oleic oil from soy “is the first product from a genome-edited plant to enter the United States food supply.” Calyno manufacturer Calyxt edited the soy genome to reduce the amount of unstable linoleic acid to create an oil containing 80% oleic acid rather than 20% in unmodified oil. To do this, Calyxt inactivated two fatty acid desaturase genes that reduce the production of the unstable linoleic acid.&nbsp;</li></ul>Nature author Chris Voigt provides a futuristic look at what else might be done with synbio such as bee-copters to transport people and trees that grow into houses. Scientists are looking to create biology-derived components. Voigt says that “[t]he next decade will see more products that derive their superior performance and affordability from engineered biology.”&nbsp;<a href="https://www.genome.gov/about-genomics/policy-issues/Synthetic-Biology" target="_blank" rel="noopener noreferrer">Genome.gov</a> provides some examples of what scientists are producing with synthetic biology,:<blockquote><ul><li>Microorganisms harnessed for bioremediation to clean pollutants from our water, soil and air.</li><li>Rice modified to produce beta-carotene, a nutrient usually associated with carrots, that prevents vitamin A deficiency. Vitamin A deficiency causes blindness in 250,000 - 500,000 children every year and greatly increases a child's risk of death from infectious diseases.</li><li>Yeast engineered to produce rose oil as an eco-friendly and sustainable substitute for real roses that perfumers use to make luxury scents.</li></ul></blockquote><h2>What could go wrong?</h2>According to Thomas, original GMOs which involved moving a single gene from one organism to another consistently produced unexpected results. Synthetic biology which is more complex will certainly lead to a greater degree of unexpected results. One such scenario, he said, would involve an organism engineered to break down cellulose that gets out into the environment:<blockquote>Let’s say you have an organism engineered to break down cellulose. If it got out into the environment, there is plenty of cellulose in our houses, clothes and fields to survive on. And we don’t know how it would change with evolution or whether it would produce toxins. Those are some of the worrying scenarios.</blockquote>Thomas wasn't pulling an example out of the air, either. He recounted a previous experience with a GMO bacteria that was designed to break down cellulose, but astute researchers discovered that it would yield unwanted results and were able to halt its release before it could do damage:<blockquote>Klebsiella planticola was a bacterium genetically engineered to break down cellulose. Fortunately, a couple of researchers looking at its impacts in the soil found that it would produce an alcohol that would kill plant roots and they were able to halt the release before it happened</blockquote>Living systems have a will to live.<blockquote>In fact, a lot of the initial work in synthetic biology sought to engineer organisms to break down cellulose into alcohol for ethanol production. If instead you break down cellulose and turn it into vanilla and that gets into the soil, we don’t know if that’s a problem. And that’s assuming that it’s going to do the thing it’s expected to do. These are living systems that evolve and have a will to live.</blockquote>New Hope further quoted Dana Perls saying that we don't understand nature well enough to know that what we are doing is totally safe.&nbsp;<blockquote>&nbsp;The problem is we don’t understand enough about how nature works to do it in a way that we can be sure is safe for human health and the environment and sustainable for small farmers.Despite biotech and agribusiness’s insistence that synbio is safe and eco-friendly, nobody knows for sure whether that’s true. Unlike first-generation GMOs—primarily plants modified with DNA from another species—this new form of gene editing is totally unregulated. USDA and FDA limit their oversight of genetically engineered products to those containing foreign DNA, which synbio ingredients typically do not have. Thus, the DARK Act of 2018, which mandates labeling of “bioengineered” foods, is of little use.</blockquote>Claims of “natural” are not accurate.<blockquote>New biotech companies are trying to pull the wool over FDA and USDA by claiming to be making ‘nature-identical’ products. But these products are not natural and are far from identical—they are genetically engineered.</blockquote><h2>Consumers and food manufacturers in the dark</h2>Consumers, New Hope's Junti wrote, are mostly unaware of synbio, even those who want GMOs labeled. And, it's not just the consumers who don't know what they're buying, she says, but the “[m]any food and dietary supplement manufacturers are also unaware of the true identity of ingredients they’re purchasing.”Related articles:<ul><li><a href="https://frontline.news/post/got-milk-it-may-not-be-real">Got milk? It might not be real</a>&nbsp;</li><li><a href="https://frontline.news/post/equating-lab-grown-meat-with-animal-meat-is-kooky-thinking-alliance-for-natural-health" target="_blank" rel="noopener noreferrer">Equating lab-grown meat with animal meat is 'kooky thinking' - Alliance for Natural Health</a></li><li><a href="https://frontline.news/post/lab-grown-meat-not-slaughter-free-not-climate-friendly-as-claimed-can-it-cause-cancer-too">Lab-grown meat not slaughter-free, not climate-friendly as claimed. Can it cause cancer too?</a></li><li><a href="https://frontline.news/post/a-little-bit-of-pfizer-in-your-cheese-fake-rennet-bypassed-additive-approval-process">A little bit of Pfizer in your cheese? Fake rennet bypassed additive approval process</a></li><li><a href="https://frontline.news/post/can-t-digest-cheese-maybe-you-can-tolerate-cheese-made-with-natural-rennet-instead-of-pfizer-s-gmo-version">Can't digest cheese? Maybe you can tolerate cheese made with natural rennet instead of Pfizer's GMO version</a></li><li><a href="https://frontline.news/post/fake-milk-inferior-to-real-milk-experts-find">Fake milk inferior to real milk, experts find</a></li><li><a href="https://frontline.news/post/fake-meat-sales-plummet-amid-falling-demand">Fake meat sales plummet amid falling demand</a></li><li><a href="https://frontline.news/post/fake-meat-industry-continues-to-plunge">Fake meat industry continues to plunge</a></li><li><a href="https://frontline.news/post/italy-becomes-first-country-to-ban-fake-food">Italy becomes first country to ban fake food</a></li><li><a href="https://frontline.news/post/fakefood-another-safe-ingredient-may-pose-health-threat">#FakeFood: Another ‘safe’ ingredient may pose health threat</a></li></ul>

DNA genetic engineering.jpg

Technology

'These products are not natural and are far from identical—they are genetically engineered'

What is synthetic biology and why should you care?

<h2 style="margin-left:0px;">Faux milk gaining ground</h2>The synbio (synthetic biology) industry is developing synthetic animal proteins including <a href="https://frontline.news/post/equating-lab-grown-meat-with-animal-meat-is-kooky-thinking-alliance-for-natural-health" target="_blank" rel="noopener noreferrer">lab-grown meat</a> and <a href="https://frontline.news/post/got-milk-it-may-not-be-real" target="_blank" rel="noopener noreferrer">synbio milk</a>. In its coverage of synbio milk, Frontline News referred to a review by Su-Jit Lin of the HuffPost about Bored Cow, a company selling its synbio milk as "The first milk alternative to do it all."&nbsp;“All,” in this sense, means animal-free, vegan-friendly, nutritionally equivalent to milk, and useful in foods, cooking, and baking in the same ways as real milk, as Frontline News reported:<blockquote>Lin reported Ben Berman, co-founder, and CEO of Bored Cow, made, stating that Bored Cow was created to “replicate the taste, texture, nutrition and functionality of conventional dairy milk” and has a nutrition panel nearly identical, if not better than the generic milk he had in his fridge.&nbsp;</blockquote>Several other companies, as Frontline News highlighted, were also producing faux milk and cheese products, making the same claims as Bored Cow, that their products are good for animals, people, and the environment. &nbsp; &nbsp;<h4 style="margin-left:0px;">Reason to doubt</h4>Frontline News has previously reported on <a href="https://frontline.news/post/lab-grown-meat-not-slaughter-free-not-climate-friendly-as-claimed-can-it-cause-cancer-too" target="_blank" rel="noopener noreferrer">claims</a> by manufacturers of lab-grown meat which didn't hold up. Similarly, <a href="https://frontline.news/post/child-slave-labor-in-producing-ev-batteries-raises-serious-questions-about-clean-green-technologies" target="_blank" rel="noopener noreferrer">claims</a> by proponents of EV cars turned out to be dubious. It was, therefore, natural to wonder about the veracity of claims made by synbio milk manufacturers.<blockquote>Considering the magnitude of the synbio dairy industry, it is important to ask if the claims made by Bored Cow and other synbio dairy manufacturers are accurate.&nbsp;</blockquote>That is the topic of this article.<h2 style="margin-left:0px;">What could possibly go wrong?</h2>Despite Lin's enthusiastic report, there are many problems associated with synbio milk.<h3 style="margin-left:0px;">Specious claims</h3>Faux milk is promoted as being the same as real milk since the “precision fermentation” process used is based on a yeast genetically modified to produce whey protein, as <a href="https://anh-usa.org/frankenfoods-v2-exploiting-the-bioequivalence-principle/" target="_blank" rel="noopener noreferrer">explained</a> by the Alliance for Natural Health:<blockquote>Bored Cow is made with whey protein produced through a process called “precision fermentation,” a form of synbio. This involves taking a gene for whey protein and inserting it into a GE yeast. The yeast is put into fermentation tanks with other nutrients to help it grow. At the end the GE yeast is supposed to be filtered out, leaving only the milk protein. Bored Cow takes this protein and adds vitamins, minerals, and other ingredients to mimic the taste, consistency, and nutritional content of real cow’s milk.</blockquote>As Lin reported, Ben Berman, co-founder, and CEO of Bored Cow, boasted that his company's synthetic milk is as good as cow's milk. Berman said that Bored Cow has a nutrition panel nearly identical, if not better, than the generic milk he had in his fridge. &nbsp;However, as ANH explained, it is not likely that synbio milk is equivalent to real milk, because of the complexity of real milk. Cow's milk is more than just the vitamins listed on the nutrition panel.<blockquote>[It is not] very likely that Bored Cow is nutritionally equivalent to real milk. Just as meat is more than just protein, milk is far more than a simple combination of whey and various vitamins and minerals. Milkfat contains 400 different fatty acids. Milk has two types of proteins, whey and casein—and there are several different types of these two proteins contained in milk, and a whole bundle of other compounds like lactoferrin and bioactive peptides that help prime the immune system.</blockquote><h3 style="margin-left:0px;">Nutritional dark matter - 92 unknown compounds&nbsp;</h3>When the Iowa-based Health Research Institute (HRI) tested Bored Cow's faux milk using full-spectrum molecular analysis technology, they discovered 92 compounds that are yet to be identified, and the presence of which are not noted on the nutritional panel. As Ken Rosenboro, editor for the Organic and Non-GMO Report <a href="https://non-gmoreport.com/not-so-precise-fermentation-lab-finds-92-unknown-compounds-in-synthetic-biology-milk/" target="_blank" rel="noopener noreferrer">wrote</a>, HRI's chief science officer John Fagan was concerned that they could not identify those compounds.<blockquote>Calling them completely novel to our food,” he says. “They are things that we haven’t consumed as human beings.”Fagan scanned scientific literature and databases to determine whether the molecules had nutritional or other beneficial properties and found nothing.“I couldn’t even find the scientific name for the vast majority of the molecules present in the Bored Cow product. They are nutritional dark matter,” Fagan says.Fagan speculated that the unknown molecules could either be nutrients or waste products created during the fermentation process, stating that if they are waste products you wouldn't “necessarily want them in your food.”</blockquote><h3 style="margin-left:0px;">GMO without the designation</h3>Rosenboro noted that Bored Cow and Perfect Day, the company that manufactures the whey protein Bored Cow uses, avoid using the term genetically engineered to describe the yeast used in the production of the whey protein, preferring “microflora” instead.&nbsp;<blockquote>Bored Cow and Perfect Day use the term “microflora” to avoid using “genetically engineered” or “GMO.”&nbsp;</blockquote><h3 style="margin-left:0px;">Not cow protein&nbsp;</h3>As if the 92 unidentifiable compounds were not enough of a problem, HRI also found that the fake milk's protein, assumed to be cow protein, was mostly from the GMO yeast and not the milk protein.&nbsp;<blockquote>Perfect Day and Bored Cow both claim the milk protein is identical to the protein in cow’s milk but HRI’s tests found that the protein in Bored Cow’s milk was mostly from the GMO yeast and not the milk protein.</blockquote>The amino acids in the product were also different from those in real milk.<blockquote>“The amino acid composition of the protein that’s present in the Bored Cow milk is strikingly different from the amino acid composition of real milk,” Fagan says. “We have data that shows this is the case.”</blockquote><h3 style="margin-left:0px;">Have some GMO DNA with your Bored Cow</h3>Fagan said that the GMO-derived microflora or yeast, which was supposed to have been removed during fermentation, was still found in the final product, Rosenboro also reported:<blockquote>“The (genetically engineered) DNA in these products is broken up or fragmented but is certainly still there,” Fagan says.Further he says tests are being developed to detect the GMO DNA in synthetic biology products like Bored Cow.</blockquote>GMO DNA in synbio products would have to be labeled as such under the bioengineered food disclosure law.<blockquote>“The reality is that all that’s required is to do a little bit of molecular biology and a GMO test can be developed for synbio products,” says Fagan who pioneered creating laboratory tests for GMO corn and soybeans when they were first commercialized in the late 1990s.The presence of GMO DNA in Bored Cow and other synbio products would mean that they would have to be labeled under the U.S. Department of Agriculture’s National Bioengineered Food Disclosure law. Right now, such products don’t require labeling.</blockquote><h3 style="margin-left:0px;">No safety assessments</h3>Rosenboro explained that the FDA does not require safety assessments for synbio milk. That milk, however, with its 92 unknown compounds, would have to undergo testing in Europe and Canada as a novel food.&nbsp;ANH <a href="https://anh-usa.org/frankenfoods-v2-exploiting-the-bioequivalence-principle/" target="_blank" rel="noopener noreferrer">elaborated</a> on the lack of safety assessment, explaining that Perfect Day, the manufacturer of the synbio whey protein used by Bored Cow, like some food manufacturers, claimed on its own that its product was GRAS (generally recognized as safe), utilizing the FDA's expedited process of GRAS <a href="https://qualitysmartsolutions.com/self-affirmed-gras/" target="_blank" rel="noopener noreferrer">self-affirmation</a> which does not require FDA review.<blockquote>The FDA must be on top of this, right? Wrong. Bored Cow has not undergone safety testing at the FDA. Perfect Day, the manufacturer of the synbio whey protein, determined it was “generally recognized as safe” (GRAS) and voluntarily notified the FDA of this determination; in response the FDA said it had no questions. Given how rife the GRAS process is with conflicts of interest, this is akin to taking the company’s word for it that its novel synbio whey protein is safe.</blockquote><h3 style="margin-left:0px;">Climate-friendly? Not so fast&nbsp;</h3>Rosenboro referred to an article in Forbes by Errol Schweizer, partner of food and agriculture at Impakt, IQ, who questioned the claim that synbio is sustainable and climate-friendly. He wanted to know how the waste material would be disposed of; the amount of energy and resources used as compared to animal-based products; and the use of high-fructose corn syrup to feed the yeast as corn production is energy intensive and polluting.&nbsp;<h3 style="margin-left:0px;">Biology doesn't work like a computer program</h3>Synbio products are being likened to a computer program so all that needs to be done is to program the DNA like a computer, a flawed assumption according to Fagan. The analogy doesn't hold water, he says, since even yeast is infinitely more complicated than computer programs.<blockquote>An article in FoodNavigator USA even describes GMO yeasts being “programmed” to produce proteins. The problem is that the internal functioning of even the simplest organisms like a yeast is vastly more complex than computer programs.“It is a hollow analogy because it implies that you have the same kind of precise control in synthetic biology that you have programming a computer. It’s much more complex,” Fagan says. “Here we have an example of 92 unpredicted compounds being produced, and only a trace of the whey protein that you really want. It’s nothing like precision.” &nbsp;</blockquote>In the tweet below, Millions Against Monsanto links to a lecture by John Fagan about precision fermentation.<blockquote><div class="raw-html-embed"><blockquote class="twitter-tweet">Listen to Dr. John Fagan’s Concerning New Findings: <a href="https://t.co/FruJ15ACrz">https://t.co/FruJ15ACrz</a> "His latest research takes aim at the synthetic biology industry, also called 'precision fermentation.'" <a href="https://t.co/3ZCZdgRuWW">pic.twitter.com/3ZCZdgRuWW</a>— Millions Against Monsanto (@againstmonsanto) <a href="https://twitter.com/againstmonsanto/status/1759246872303087825?ref_src=twsrc%5Etfw">February 18, 2024</a></blockquote> <script async="" src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div></blockquote>Related articles:<ul><li><a href="https://frontline.news/post/danger-ahead-changing-the-natural-world-with-genetic-engineering-and-artificial-intelligence" target="_blank" rel="noopener noreferrer">Danger ahead! Changing the natural world with genetic engineering and artificial intelligence</a></li><li><a href="https://frontline.news/post/got-milk-it-may-not-be-real" target="_blank" rel="noopener noreferrer">Got milk? It might not be real</a></li><li><a href="https://frontline.news/post/equating-lab-grown-meat-with-animal-meat-is-kooky-thinking-alliance-for-natural-health" target="_blank" rel="noopener noreferrer">Equating lab-grown meat with animal meat is 'kooky thinking' - Alliance for Natural Health</a></li><li><a href="https://frontline.news/post/lab-grown-meat-not-slaughter-free-not-climate-friendly-as-claimed-can-it-cause-cancer-too">Lab-grown meat not slaughter-free, not climate-friendly as claimed. Can it cause cancer too?</a></li><li><a href="https://frontline.news/post/a-little-bit-of-pfizer-in-your-cheese-fake-rennet-bypassed-additive-approval-process">A little bit of Pfizer in your cheese? Fake rennet bypassed additive approval process</a></li><li><a href="https://frontline.news/post/can-t-digest-cheese-maybe-you-can-tolerate-cheese-made-with-natural-rennet-instead-of-pfizer-s-gmo-version">Can't digest cheese? Maybe you can tolerate cheese made with natural rennet instead of Pfizer's GMO version</a></li><li><a href="https://frontline.news/post/fake-milk-inferior-to-real-milk-experts-find">Fake milk inferior to real milk, experts find</a></li><li><a href="https://frontline.news/post/fake-meat-sales-plummet-amid-falling-demand">Fake meat sales plummet amid falling demand</a></li><li><a href="https://frontline.news/post/fake-meat-industry-continues-to-plunge">Fake meat industry continues to plunge</a></li><li><a href="https://frontline.news/post/italy-becomes-first-country-to-ban-fake-food">Italy becomes first country to ban fake food</a></li><li><a href="https://frontline.news/post/fakefood-another-safe-ingredient-may-pose-health-threat">#FakeFood: Another ‘safe’ ingredient may pose health threat</a></li></ul>

milk in test tubes.jpg

No FDA safety testing

'Nutritional dark matter' in Bored Cow's synbio milk - 92 unknown compounds

This Wednesday, the senior editor of NPR, Uri Berliner, announced that he would be resigning from the organization for which he has worked for the past 25 years.<div class="raw-html-embed"><blockquote class="twitter-tweet">My resignation letter to NPR CEO <a href="https://twitter.com/krmaher?ref_src=twsrc%5Etfw">@krmaher</a> <a href="https://t.co/0hafVbcZAK">pic.twitter.com/0hafVbcZAK</a>— Uri Berliner (@uberliner) <a href="https://twitter.com/uberliner/status/1780610524411048183?ref_src=twsrc%5Etfw">April 17, 2024</a></blockquote> <script async="" src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>The day before he tendered his resignation, Berliner had been suspended from NPR for five days without pay, due to the criticism of his colleagues regarding a piece he wrote for The Free Press, excoriating NPR for its progressive bias.&nbsp;&nbsp;The apology as a weaponInstead of resigning, Berliner could have apologized, recanted, and moved on — as many have done before him, especially when they cannot afford to lose their source of income. The more people take this route, the harder it is to be the outlier, especially as that outlier can be ostracized not only at work but also in his entire social circle, and perhaps even among family and relatives.In an environment where backing down and repenting one's “unwoke” ideas is increasingly idolized, groupthink becomes swiftly embedded and harder to resist.According to Dr. James Lindsay, embedding groupthink is part of the plan, and the plan was hatched not in the United States but in China, where its finer points were tested on the native population before being exported in order to destabilize and weaken China's main rival on the world stage.<div class="raw-html-embed"><iframe width="681" height="383" src="https://www.youtube.com/embed/MjQp-ZLu0oI" title="James Lindsay on Struggle Sessions: Have Chinese Political Warfare Tactics Influenced American DEI?" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen=""></iframe></div>Dr. Lindsay explains that the “crimes” of the DEI age are intentionally vague.<blockquote>They're training you to recognize your crimes on a predetermined set of terms … and their goal is to pressure you psychologically into figuring out in their terms how you harmed other people.</blockquote>He notes the extensive use of the word “harm," a typically vague term that is essentially impossible to prove or refute.When a person is accused by someone in the workplace or any other setting of having “harmed” someone, he continues, what happens is that the person's social milieu is “weaponized” against them. The person comes under tremendous psychological pressure to “just apologize” and restore the good name of the company, social group, family etc.<blockquote>This is psychological torture that's effected through manipulating the social environment around you to create psychological struggle so that you recognize crimes that are ill-defined in reality…It ends with you selling yourself out.</blockquote>&nbsp;DEI or DIE?Berliner is a prominent example of what is happening in workplaces in many places around the world, where those who dare to resist the prevailing worldview of the institution (even, or perhaps especially, if said institution is supposedly practicing even-handed, <a href="https://thehill.com/opinion/campaign/3950550-the-truth-about-nprs-funding-and-its-possible-future/" target="_blank" rel="noopener noreferrer">government-sponsored</a> journalism) are aggressively weeded out.According to a recent representative <a href="https://freespeechunion.org/the-edi-tax-how-equity-diversity-and-inclusion-is-hobbling-british-businesses/?mc_cid=1c18d61fed&amp;mc_eid=33114c8522&amp;utm_source=substack&amp;utm_medium=email" target="_blank" rel="noopener noreferrer">survey</a> conducted in the U.K., training in DEI (referred to in Britain as EDIC—Equity, Diversity, Inclusion and Climate) is endemic in the British workplace. 65% of those surveyed said that they had been obliged to undergo some form of diversity training by an employer.Among those who underwent DEI training, the majority reported that they had felt compelled to hide their true opinions of the content. Over one in five said they had “said what they ought to say rather than what they thought.” Among Black and Asian respondents, this proportion rose to almost one in three. Apparently, their caution was well-founded, as 36 percent of those surveyed said that they had witnessed staff being penalized for challenging DEI training and 12 percent said they had seen staff fired.Almost half of those surveyed who went through training said that what they were forced to learn conflicted with their values, and almost a third of respondents said that they had left a job because their employer adopted “woke” ideology. Here, too, the proportion was higher among minority groups and also among those who identify as LGBT.&nbsp;The survey did not examine the reasons why those identifying as LGBT should object to woke ideas, but recent activity on the part of organizations such as <a href="https://www.theguardian.com/society/2022/sep/14/lie-of-gender-identity-spurred-founding-of-lgb-alliance-court-told" target="_blank" rel="noopener noreferrer">LGB Alliance </a>against trans-promoting groups perhaps gives a clue to where they are coming from. While woke-trans is an ideology, many who call themselves L, G, or B do not allow their form of intimate attraction to define their entire identity and object to giving it so much prominence.The report's authors concluded that DEI is operating,<blockquote>… in effect, as a tax … Many ambitious employees and senior managers are leaving companies because of the excessive time they're expected to spend on these courses … Genuine diversity of thought is required for any business to thrive, but much EDIC training is having the opposite effect and embedding a new form of groupthink.</blockquote>According to Dr. Lindsay, this is exactly the plan being implemented by influential elements who have succeeded in permeating virtually all U.S. institutions, from the armed forces to the universities, corporations to smaller businesses, government local and federal — essentially, everywhere. Whether or not the United States will be next to adopt draconian thought-police laws like those now in place in Scotland remains to be seen.

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